http://www.nealelab.is/home daily 1.0 2020-07-20 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1516982834362-FGUTWKYLIYS90OY7B1R9/_DSC9969.JPG Home https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1473116479077-ZHVEX6RRIIB84HQGMB1Z/SCZ_GWAS_108loci.jpg Home http://www.nealelab.is/blog daily 0.75 2019-10-24 http://www.nealelab.is/blog/2019/10/24/updating-snp-heritability-results-from-4236-phenotypes-in-uk-biobank monthly 0.5 2019-10-25 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1571922513402-BB0JSVOQNRSSS7NI7LCI/Screenshot+2019-10-24+09.06.15.png Blog - Updating SNP heritability results from 4,236 phenotypes in UK Biobank We observe slightly stronger SNP-heritability results when the phenotype is rank-normalized for the GWAS rather than analyzed on the raw scale of the phenotype recorded by UK Biobank. Screenshot from: https://nealelab.github.io/UKBB_ldsc/select_topline.html#continuous_phenotype_normalization https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1571923038510-MDU5Q84GD7SHVRJKXOW8/Screenshot+2019-10-24+09.16.47.png Blog - Updating SNP heritability results from 4,236 phenotypes in UK Biobank Screenshot from: https://nealelab.github.io/UKBB_ldsc/significance.html#distribution_of_(h^2_g)_results http://www.nealelab.is/blog/2019/10/10/genetic-correlation-results-for-heritable-phenotypes-in-the-uk-biobank monthly 0.5 2019-10-25 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1570722414151-Y2A03P9I26NCX3JMNDN8/image2.png Blog - Genetic correlation results for heritable phenotypes in the UK Biobank https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1570722484887-XSQGI5WUFNWGKANF32OR/image1.png Blog - Genetic correlation results for heritable phenotypes in the UK Biobank https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1570722902714-PV0JBF9ZVXRVUFK5GK68/image4.png Blog - Genetic correlation results for heritable phenotypes in the UK Biobank https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1570722984906-Y4QQ58CQ8QGFJHBNU5KG/image6.png Blog - Genetic correlation results for heritable phenotypes in the UK Biobank http://www.nealelab.is/blog/2019/9/17/genotyped-snps-in-uk-biobank-failing-hardy-weinberg-equilibrium-test monthly 0.5 2019-09-18 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1568773967578-SLVRJTPP5YUFPV2EWH41/Screenshot+2019-09-17+22.31.08.png Blog - Genotyped SNPs in UK Biobank failing Hardy-Weinberg equilibrium test Scatterplot of SNP intensity for rs2237897 in UK Biobank courtesy of http://mccarthy.well.ox.ac.uk/ScatterShotWebApp/ui/scattershot and brought to our attention by Adam Butterworth (@aidanbutty). Thanks Adam! http://www.nealelab.is/blog/2019/9/16/biomarkers-gwas-results monthly 0.5 2019-10-10 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1568664057632-ONTWHNAM2KRKOG0ZNT9C/image1.png Blog - GWAS of UK Biobank biomarker measurements https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1568664272936-Z8YW292B2UD5TNY2Z3R3/image2.png Blog - GWAS of UK Biobank biomarker measurements http://www.nealelab.is/blog/2017/9/20/insights-from-estimates-of-snp-heritability-for-2000-traits-and-disorders-in-uk-biobank monthly 0.5 2017-09-20 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925032527-NRESJIPAHEUE61FWNRJY/int_hist_neff10k.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Distribution of LDSR intercept estimates for phenotypes with \(N_{eff}\) > 10,000. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925459117-IE6H0E3WGUWITY4NCFCX/image-asset.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank QQ plots for the significance of the estimated heritability in univariate (blue) and partitioned (orange) LDSR for all phenotypes. Both plots restricted to phenotypes with univariate LDSR results. Interactive versions of these plots can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505924930534-HFHCG2TCXP98NOD0XO3Q/h2_qq.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank QQ plot of significance for all heritability estimates. Interactive versions of these plots can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925277348-XTQZCKD2KX2W7CBCWBG9/int_univar.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Comparison of estimated intercept from univariate and partitioned LDSR. Orange reference line indicates equal values. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925187366-L2P8WIPBKN7XADFDPCFY/ratio_hist_neff50k.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Distribution of LDSR ratio estimates for phenotypes with \(N_{eff}\) > 50,000. An interactive versions of this plot can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925642240-NXQUMCZJPC9GCBGWQM7S/h2_hist_smallbin.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Distribution of liability-scale heritability estimates for 854 binary phenotypes with effective sample sizes between 200 and 1000. Effective sample sizes below 200 omitted for clarity. An interactive version of this plot can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505924914695-EZUUK5Y8D2VLACX5HV1I/h2_hist_neff10k.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Distribution of LDSR SNP-heritability estimates for phenotypes with \(N_{eff}\) > 10,000. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925569534-JP018E0J9YE798NZ1CRB/h2_sampsize.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Loess fit of average estimated heritability as a function of effective sample size. Zoomed to show detail at small sample sizes. Phenotypes with \(N_{eff}\) < 100 omitted to avoid outliers with extreme heritability estimates. An interactive version of this plot can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925105899-T1H80ZYZ3XU45SN52MYG/int_qq.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank QQ plot of significance for all intercept estimates. Interactive versions of these plots can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925392018-IW891AIG93Z1VE7UVCN4/h2_univar.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank Comparison of estimated \(h^2\) from univariate and partitioned LDSR for phenotypes with \(N_{eff}\) > 10,000. Orange reference line indicates equal values. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925327595-VCK1P2K9V9ANNP5KR62L/int_qq_univar.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank QQ plots for the significance of the intercept term in univariate (blue) and partitioned (orange) LDSR. Both plots restricted to phenotypes with univariate LDSR results. Interactive versions of these plots can be found on the UKBB heritability results site. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505925507965-5FNCB923UCULHMJWXASZ/qq_annot.png Blog - Insights from estimates of SNP-heritability for >2,000 traits and disorders in UK Biobank QQ plot of significance of coefficient for genomic annotations in partitioned LDSR. An interactive version of this plot, including a full legend for the 38 plotted annotations, can be found on the UKBB heritability results site. http://www.nealelab.is/blog/2017/9/14/heritability-501-ldsr-based-h2-in-ukbb-for-the-technically-minded monthly 0.5 2017-09-20 http://www.nealelab.is/blog/2017/9/13/heritability-201-types-of-heritability-and-how-we-estimate-it monthly 0.5 2019-04-23 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505348980048-CTATYV6GBNC22C6B6RQK/F1.large.jpg Blog - Heritability 201: Types of heritability and how we estimate it https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505404537682-49ULXLDW5KNTASLYFYF6/800px-Jelly_Belly_jelly_beans_%283%29%2C_December_2008.jpg Blog - Heritability 201: Types of heritability and how we estimate it http://www.nealelab.is/blog/2017/9/13/heritability-101-what-is-heritability monthly 0.5 2017-09-20 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505843319106-GOR1YDIV4SCH3W88R167/heritability101.png Blog - Heritability 101: What is “heritability”? Schematic diagram of contrasting roles of genes and environment in development of personality. One-headed arrows link causes to effects; two-headed arrows indicate correlations. Genes and environments are both causal inputs into an interactive developmental system (represented by the network of arrows in the center of the figure), but because people select and shape their own environments (as represented by lighter one-headed arrows from personality to environments), correlations across the developmental system (dotted two-headed arrows) are easier to detect for genes than for environments. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505339859669-WGXW4VAIWUVM3F5LKXQC/Screen+Shot+2017-09-13+at+5.55.19+PM.png Blog - Heritability 101: What is “heritability”? http://rene.maltete.com/index.php/humour/maths https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505855250149-TXNONO8PJ3U9N11LD1RE/Screen+Shot+2017-09-19+at+5.06.09+PM+%282%29.png Blog - Heritability 101: What is “heritability”? http://johnhawks.net/explainer/stats/heritability-and-stature/ http://www.nealelab.is/blog/2017/9/11/details-and-considerations-of-the-uk-biobank-gwas monthly 0.5 2017-09-20 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222222744-ERJ5IA1GYUP5OY4EHN0W/10.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221854230-WSPKF5HEWWJZTDAA3SYY/4.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221552560-6F4AKR8VPVC633QM7YQW/1.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222278587-ZGTUB401HHFVRGXGLVSA/11.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221651581-TZS9YLIH9BGWKGUUPZGS/2.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221786175-LRDZEEWN3MS7FS5DTAFQ/3.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221985244-FI2VKSFV2FU8QKYMZKT6/6.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222170411-FI0Q7CZBY6WKSIIM77Q2/9.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222050416-0JCK17L0EUUHV6CEPWT9/7.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222343327-00FSO1QDVM1DRLSBOKO1/12.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505221922565-HBRA0GTURW9QWQ9TSXB8/5.png Blog - Details and considerations of the UK Biobank GWAS https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505222108305-KXHIGTWBLS1CG0RYWGZN/8.png Blog - Details and considerations of the UK Biobank GWAS http://www.nealelab.is/blog/2017/9/15/heritability-of-2000-traits-and-disorders-in-the-uk-biobank monthly 0.5 2017-09-20 http://www.nealelab.is/blog/2017/7/19/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank monthly 0.5 2017-10-03 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1505852757421-FRNK2CCO8VN1948SWCT5/UKBBHighRes.jpeg Blog - Rapid GWAS of thousands of phenotypes for 337,000 samples in the UK Biobank http://www.nealelab.is/media daily 0.75 2020-02-21 http://www.nealelab.is/contact daily 0.75 2017-09-18 http://www.nealelab.is/data daily 0.75 2017-08-03 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474566732693-9VJ0EGP3SI9AYCJ3VNIN/image-asset.jpeg DATA https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474570774002-0ARKSCI9B38P695G39F9/image-asset.jpeg DATA https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474568316292-OHZOSWA3K4GNHRXVG35F/image-asset.jpeg DATA https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1501152655260-7NLO32D8TZIDINVO4LLA/image-asset.png DATA https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1501114934781-F65V0GUNPNCCOO7Y3BXS/image-asset.png DATA http://www.nealelab.is/methods-development daily 0.75 2018-06-13 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474910843552-ZW1G1LT7P8J0AH62JWB6/image-asset.gif Methods https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474650461342-YBIQ1UH2T98PZX9DYXD5/Screen+Shot+2016-09-23+at+1.06.54+PM.png Methods https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474647637024-3RGZFP48RU0257SGE4V6/ldscore.jpg Methods https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1501120544382-M7TPGP1JLJN5XGAH0C3D/image-asset.jpeg Methods https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474647823743-XWX6NN5WIP9U8Q8PQ10V/gencorr.jpg Methods https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1474905548500-EIA2H6R6Q35AY275KP1B/image-asset.jpeg Methods http://www.nealelab.is/tools-and-software daily 0.75 2018-06-13 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1473350738993-GXM4T5VOSF6QKFM4UW5K/ldhub.png Software https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1472847125364-L8OZG089JA9O7BNO9NZD/pedigree.png Software https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1501118969735-C9Z4ZLHAPHIR0DLVN52Q/hail_logo_20.png Software http://www.nealelab.is/people daily 0.75 2025-10-01 https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/f3bb255e-e03e-4dde-95e6-bb3c6ce17381/WenhanLu_Headshot-480x480.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/272f64b2-26cc-43de-bc66-9c6f7a23b666/Franjo-Ivankovic-480x480.jpeg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1ca37c5d-7f24-4055-87ca-cd6e31cadc1f/Kush+Chandra.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/1558121801778-MGX2EB2B21WD343E2MJK/FeleciaCerrato_headshot.jpg People https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/3749b997-8d96-457a-9bf8-fdfee6de006b/Robel%2BAlemu.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57b3657b6a496370ca7dfb39/e18f309a-2183-460d-832c-a0e480e8b952/Bob_Ye_003.JPG People - 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